Jamie-Lynn Sigler knows that living with chronic illness is an uphill battle. 

The Sopranos star recently gave more insight into her over two-decade long journey with multiple sclerosis, including a near-death experience in 2023. 

"A little less than a year ago now is when I went to India, and I lived at this ashram, and I had felt so awakened and connected and peaceful," she explained on the June 4 episode of the MeSsy podcast, which was recorded earlier in 2024. "Two weeks later, I had a very bad reaction to a surgery and got sepsis and was in the hospital and almost died."

But despite the harrow experience, she kept the dire circumstances surrounding her hospitalization close to her chest.

"I never told anybody this," she told cohost Christina Applegate,  "I was this much away from death."

Following the major health scare, the 43-year-old deemed 2023 her year of "grieving."

"I had never in my life been more sad," Jamie-Lynn recalled. "Felt more low. But what I learned from India was that I have an inability to escape it. I had to sit in it. I would scream in pillows. I would cry to girlfriends. I reached out. I sat by myself. I got a therapist. I did all of these things I had never really done before and went through this process that was absolutely necessary."

Despite the difficulties, the Entourage alum—who shares sons Beau, 10, and Jack, 6, with husband Cutter Dykstra—used her story to motivate her cohost through her own dark time as she battles the same illness. 

"It's so hard to live in a disabled body," Jamie-Lynn continued. "I will not take that away from you and I'm right there with you. But what makes it harder is when you compare it to how it used to be." 

For her part, Christina, who shared her own MS diagnosis in 2021, has been struggling amid acclimating to life with a chronic illness. 

"I'm still sitting here like ‘Boohoo, woe is me.' I'm still mad about it," the Married… With Children actress shared. "I am in a depression right now, which I don't think I've felt for years, like a real, f--k it all, like real depression where it's kind of scaring me too a little bit because it feels really fatalistic.

In addition to sharing her own ups-and-downs with MS, Jamie-Lynn encouraged her friend to seek support from a therapist and loved ones. 

"I see more light in that process for you," she noted. "I can't let you give up. I can't do it. I need you to do it."