Week 1 brought several unexpected twists and turns. The New England Patriots beat the Cincinnati Bengals to everyone's shock. The New Orleans Saints had a massive performance in their win over the Carolina Panthers. Baltimore's Isaiah Likely outshined star teammate Mark Andrews. It was a fresh change of pace, and it made everyone realize that trying to predict what will happen in the NFL is a fool's errand.

So, we're back trying to do exactly that! With Thursday Night Football just around the corner, here are our experts' predictions for every Week 2 matchup.

New to sports betting? USA TODAY readers can claim exclusive promos and bonus codes with the best online sportsbooks and sports betting sites. Here are the NFL betting odds for Week 1, according to the BetMGM NFL odds.

PROP TALK: These are the best prop bets for NFL games this week 

NFL Week 2 picks/predictions

• Buffalo Bills at Miami Dolphins
• Las Vegas Raiders at Baltimore Ravens
• Los Angeles Chargers at Carolina Panthers
• New Orleans Saints at Dallas Cowboys
• Tampa Bay Buccaneers at Detroit Lions
• Indianapolis Colts at Green Bay Packers
• Cleveland Browns at Jacksonville Jaguars
• San Francisco 49ers at Minnesota Vikings
• Seattle Seahawks at New England Patriots
• New York Jets at Tennessee Titans
• New York Giants at Washington Commanders
• Los Angeles Rams at Arizona Cardinals
• Cincinnati Bengals at Kansas City Chiefs
• Pittsburgh Steelers at Denver Broncos
• Chicago Bears at Houston Texans
• Atlanta Falcons at Philadelphia Eagles

NFL STATS CENTRAL: The latest NFL scores, schedules, odds, stats and more.

NFL Week 2 point spreads

• Buffalo Bills (+2.5) at Miami Dolphins
• Las Vegas Raiders (+9.5) at Baltimore Ravens
• Los Angeles Chargers (-6.5) at Carolina Panthers
• New Orleans Saints (+6.5) at Dallas Cowboys
• Tampa Bay Buccaneers (+7) at Detroit Lions
• Indianapolis Colts (-3.5) at Green Bay Packers
• Cleveland Browns (+3) at Jacksonville Jaguars
• San Francisco 49ers (-6) at Minnesota Vikings
• Seattle Seahawks (-3.5) at New England Patriots
• New York Jets (-3.5) at Tennessee Titans
• New York Giants (+1.5) at Washington Commanders
• Los Angeles Rams (+1.5) at Arizona Cardinals
• Cincinnati Bengals (+6) at Kansas City Chiefs
• Pittsburgh Steelers (-3) at Denver Broncos
• Chicago Bears (+7) at Houston Texans
• Atlanta Falcons (+6.5) at Philadelphia Eagles

NFL Week 2 moneylines

• Buffalo Bills (+115) at Miami Dolphins (-140)
• Las Vegas Raiders (+350) at Baltimore Ravens (-450)
• Los Angeles Chargers (-275) at Carolina Panthers (+220)
• New Orleans Saints (+240) at Dallas Cowboys (-300)
• Tampa Bay Buccaneers (+260) at Detroit Lions (-350)
• Indianapolis Colts (-185) at Green Bay Packers (+150)
• Cleveland Browns (+145) at Jacksonville Jaguars (-175)
• San Francisco 49ers (-275) at Minnesota Vikings (+220)
• Seattle Seahawks (-185) at New England Patriots (+150)
• New York Jets (-190) at Tennessee Titans (+155)
• New York Giants (+105) at Washington Commanders (-125)
• Los Angeles Rams (+105) at Arizona Cardinals (-125)
• Cincinnati Bengals (+200) at Kansas City Chiefs (-250)
• Pittsburgh Steelers (-155) at Denver Broncos (+130)
• Chicago Bears (+260) at Houston Texans (-350)
• Atlanta Falcons (+240) at Philadelphia Eagles (-300)

NFL Week 2 over/under

• Buffalo Bills at Miami Dolphins: 49
• Las Vegas Raiders at Baltimore Ravens: 41.5
• Los Angeles Chargers at Carolina Panthers: 39
• New Orleans Saints at Dallas Cowboys: 45.5
• Tampa Bay Buccaneers at Detroit Lions: 51.5
• Indianapolis Colts at Green Bay Packers: 41
• Cleveland Browns at Jacksonville Jaguars: 41.5
• San Francisco 49ers at Minnesota Vikings: 45.5
• Seattle Seahawks at New England Patriots: 38
• New York Jets at Tennessee Titans: 40.5
• New York Giants at Washington Commanders: 44
• Los Angeles Rams at Arizona Cardinals: 49
• Cincinnati Bengals at Kansas City Chiefs: 47.5
• Pittsburgh Steelers at Denver Broncos: 36.5
• Chicago Bears at Houston Texans: 45.5
• Atlanta Falcons at Philadelphia Eagles: 47