Chelsea Handler has some thoughts on those JD Vance "cat ladies" comments.

The comedian, 49, went off in an Instagram video in response to the Ohio senator and vice presidential candidate's resurfaced comments about people who don't have children. In an interview on "Tucker Carlson Tonight" in 2021, Vance said that "we are effectively run in this country … by a bunch of childless cat ladies who are miserable at their own lives and the choices that they've made."

"This country is still controlled by men in systems that were set up by men, that are carefully crafted to continue to benefit men," Handler, who does not have children, told Vance. "So to put it in women-hating terms you'll understand, you're being hysterical."

The former "Chelsea Lately" host also said that Vice President Kamala Harris is not any less fit to serve as president because she doesn't have biological kids, as there is "no correlation between childless people and the presidency." Harris shares two stepchildren with her husband, second gentleman Douglas Emhoff.

"Maybe if she had five kids with three different men and a scandalous affair with a porn star and was a convicted felon, that would be more palatable to Republican men," Handler said. "I mean, my God, are we tired."

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The comic added, "All of us childless cat and dog ladies are going to go from 'childless and crushing it' to 'childless and crushing you' in November." In the caption of the video, she expressed support for Harris, who launched her campaign for president after President Joe Biden dropped out of the race. "Childless Cat and Dog Ladies for Harris," Handler wrote.

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In the original Fox News segment from 2021, Vance said it doesn't make sense that "we've turned our country over to people who don't really have a direct stake in it," referring to politicians without children.

Jennifer Aniston previously criticized Vance for the resurfaced comments on her Instagram Stories.

"I truly can't believe this is coming from a potential VP of the United States," the "Friends" star said. "All I can say is … Mr. Vance, I pray that your daughter is fortunate enough to bear children of her own one day. I hope she will not need to turn to IVF as a second option. Because you are trying to take that away from her, too."

In an interview with Megyn Kelly on Friday, Vance said such references to his daughter are "disgusting" because she "is 2 years old." He also said his "childless cat ladies" remark was "sarcastic" but that the "substance" of what he said is "true."

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"This is not about criticizing people who, for various reasons, didn't have kids," Vance also told Kelly. "This is about criticizing the Democratic Party for becoming anti-family and anti-child."

Whoopi Goldberg also criticized Vance's old comments on "The View," saying, "Sir, there are people who have chosen not to have children for whatever reason. There are people who want to have children who cannot. How dare you. You never had a baby. Your wife had a baby. But you never had a baby, so you know nothing about this. How dare you."

Handler has frequently discussed her decision not to have children, including when she guest-hosted "The Daily Show" last year.

"Kids don't respect me, and quite frankly, the feeling is mutual," she joked. "And the fact is, there are millions of women just like me. But for some reason, every single one of us, at some point in our lives, is shamed by society for not wanting a baby."

On "The Drew Barrymore Show," Handler said that "so many women" have reached out to thank her for what she has said about not having kids. "You're not worthy in this world when you become a mother or someone's wife. You're worthy before that."

Contributing: KiMi Robinson